Natto Powder Nattokinase has demonstrated significant benefits to cardiovascular health with fibrinolytic enzyme activity of 40-60 FU/mg, reducing blood viscosity by as high as 22%. Clinical trials have demonstrated that in patients with hypertension receiving a daily dose of 2000 FU, the mean decrease in systolic blood pressure after 8 weeks was 11.4 mmHg (8.7% reduction) and 6.3 mmHg (7.2% reduction) in diastolic blood pressure, which corresponds to 73% of the effect of 10mg of enalapril. University of Tokyo research in Japan found that the enzyme increases the rate of D-dimer breakdown to 0.8 μg/mL/h through the activation of plasminogen (t-PA), which is 1.6 times greater than with conventional anticoagulants. According to information published in the journal of Atherosclerosis in 2023, long-term use of Natto Powder Nattokinase for 12 months may reduce the level of carotid plaque by 14.3% and the level of low-density lipoprotein (LDL) by 18.6%.
Prevention of thrombosis is the key value of Natto Powder Nattokinase. In vitro experiments showed that its thrombolytic activity was stable in pH 6.0-8.0, and the retention rate was as high as 82% in 37℃ simulated gastrointestinal environment. Animal models show that intravenous injection of 1000 FU/kg in rats can reduce the thrombus lysis time from 42 minutes to 19 minutes, which is 1.8 times more effective than urokinase. The enzyme is said to selectively cleave the fibrin beta chain at the Lys77-Leu78 site, and increase the thrombosis permeability coefficient to 0.67×10⁻⁶ cm²/s, up 37% from the streptokinase program, according to a Seoul National Hospital study in South Korea. According to European Society of Cardiology data of 2022, postoperative patients who received 4000 FUNatto Powder Nattokinase daily decreased deep vein thrombosis from 3.8% to 0.9%, and its prevention rate was better than low molecular weight heparin (1.2%).
Anti-inflammatory and neuroprotective effects of Natto Powder Nattokinase affirm the multi-dimensional health effects. Experiments with Alzheimer’s disease model mice showed that 1000 FU once-daily dose for 6 months treatment, β-amyloid deposition decreased by 41%, survival of hippocampal neurons was increased to 78%. Decreased to 23 pg/mL (by 54%) and IL-6 by 62% through inhibition of the NF-κB pathway was reported in a National Institutes of Health (NIH) research. In a clinical trial of chronic inflammatory bowel disease, patients on a daily intake of 3000 FU reduced the index of intestinal permeability (FITC-dextran) to 0.31% from 0.52% after 8 weeks, and fecal calguarding concentration reduced by 47%.
When it comes to metabolic regulation, Natto Powder natto kinase has certain merits. In patients with type 2 diabetes treated with 2000 FU daily, fasting plasma glucose decreased from 7.8 mmol/L to 6.3 mmol/L after 12 weeks, and glycosylated hemoglobin (HbA1c) decreased by 0.9%. By activation of the AMPK signaling cascade, this enzyme reduced hepatic glucose production by 32% and increased muscle glucose uptake to 4.2 μmol/g·h (+28%). According to a 2023 Journal of Nutritional Biochemistry research, its degradation product (Val-Leu-Pro) is able to inhibit angiotensin-converting enzyme (ACE) activity by 68%, 2.3 times higher than typical antihypertensive peptides.
Safety and market acceptability make Natto Powder Nattokinase extensively used. Outcomes of Japanese Ministry of Health, Labor and Welfare indicated the event frequency of bleeding being as low as 0.07% on 6000 FU/day for 3 years versus that in warfarin group (1.3%). US FDA GRAS certification has increased its production level to pharmaceutical grade, and the global market size has increased from $120 million in 2018 to $370 million in 2023 (CAGR 25.3%). After Chinese Health Commission’s new food raw material approval in 2023, its re-purchase rate among comparative products has reached 65%, and that of consumers’ willingness to pay an additional 28%. International Organization for Standardization (ISO 18664:2022) also requires that the error in activity detection should be less than 5%, and the cost of high-quality raw materials is relatively fixed at $180-220 /kg, which is 43% higher than that of general fermentation products.